期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 4, 页码 542-557出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm020960r
关键词
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Three series of monoquinolines consisting of a 1,4-bis(3-aminopropyl)piperazine linker and a large variety of terminal groups were synthesized. Our aim was to prove that in related bisquinoline, it is the second quinoline moiety that is responsible for cytotoxicity and that it is not an absolute requirement for overcoming resistance to chloroquine (CQ). Eleven compounds displayed a higher selectivity index (ratio CC50/IC50 activity) than CQ and one of them cured mice infected by Plasmodium berghei.
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