期刊
JOURNAL OF IMMUNOLOGY
卷 170, 期 4, 页码 1987-1994出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.4.1987
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI019335-19, T32 AI 07411, AI 19335] Funding Source: Medline
- NICHD NIH HHS [K12 HD 00850] Funding Source: Medline
Recent studies have shown that MHC class I molecules play an important role in the protective immune response to Mycobacterium tuberculosis infection. Here we showed that mice deficient in MHC class la, but possessing MHC class Ib (Kb-/-Db-/- mice), were more susceptible to aerosol infection with M. tuberculosis than control mice, but less susceptible than mice that lack both MHC class Ia and Ib (beta(2)m(-/-) mice). The susceptibility of Kb-/-Db-/- mice cannot be explained by the failure of CD8(+) T cells (presumably MHC class Ib-restricted) to respond to the infection. Although CD8(+) T cells were a relatively small population in uninfected Kb-/-Db-/- mice, most already expressed an activated phenotype. During infection, a large percentage of these cells further changed their cell surface phenotype, accumulated in the lungs at the site of infection, and were capable of rapidly producing IFN-gamma following TCR stimulation. Histopathologic analysis showed widespread inflammation in the lungs of K(b-/-)Db(-/-) mice, with a paucity of lymphocytic aggregates within poorly organized areas of granulomatous inflammation. A similar pattern of granuloma formation has previously been observed in other types of MHC class I-deficient mice, but not CD8alpha(-/-) mice. Thus, neither the presence of MHC class Ib molecules themselves, nor the activity of a population of nonclassical CD8(+) effector cells, fully restored the deficit caused by the absence of MHC class la molecules, suggesting a unique role for MHC class la molecules in protective immunity against M. tuberculosis.
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