期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1593, 期 2-3, 页码 115-120出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4889(02)00349-X
关键词
zyxin; paxillin; focal adhesion; LIM domain; nuclear-cytoplasmic shuttling; transcription
资金
- NCI NIH HHS [CA47763] Funding Source: Medline
Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter the nucleus by association with other proteins, but are exported from the nucleus by means of intrinsic leucine-rich nuclear export sequences. Zyxin/paxillin proteins may regulate gene transcription by interaction with transcription factors. In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects. (C) 2002 Elsevier Science B.V. All rights reserved.
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