期刊
JOURNAL OF CELL BIOLOGY
卷 160, 期 4, 页码 475-479出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200207136
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The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca2+-handling proteins, namely the Ca2+-binding proteins, the Ca2+ pumps and the Ca2+ release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca2+ signals, Ca2+ homeostasis, and protein folding and quality control.
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