期刊
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
卷 14, 期 5, 页码 2865-2869出版社
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
DOI: 10.7314/APJCP.2013.14.5.2865
关键词
KIF1B; rs17401966; chronic hepatitis B infection (HBV); HCC; Thailand
类别
资金
- Higher Education Research Promotion
- National Research University Project of Thailand Office of the Higher Education Commission [HR1155A-55, HR1162A-55]
- Center of Excellence in Clinical Virology
- Research Unit of Hepatitis and Liver Cancer
- Ratchadapiseksompotch Fund (Faculty of Medicine), Chulalongkorn University
- Chulalongkorn University Centenary Academic Development Project, Integrated Innovation Academic Center
- Chulalongkorn University Centenary Academic Development Project [CU56-HR01]
- Thailand ResearchFund [BRG5580005]
- Outstanding Professor of the Thailand Research Fund [DPG5480002]
- Office of the National Research Council of Thailand (NRCT)
- King Chulalongkorn Memorial Hospital
Hepatitis B virus (HBV) infection can become chronic and if left untreated can progress to hepatocellular carcinoma (HCC). Thailand is endemic for HBV and HCC is one of the top five cancers, causing deaths among Thai HBV-infected males. A single nucleotide polymorphism (SNP) at the KIF1B gene locus, rs17401966, has been shown to be strongly associated with the development of HBV-related HCC. However, there are no Thai data on genotypic distribution and allele frequencies of rs17401966. Thai HBV patients seropositive for HBsAg (n=398) were therefore divided into two groups: a case group (chronic HBV with HCC; n=202) and a control group (HBV carriers without HCC; n=196). rs17401966 was amplified by polymerase chain reaction (PCR) and analyzed by direct nucleotide sequencing. The genotypic distribution of rs174019660 for homozygous major genotype (AA), heterozygous minor genotype (AG) and homozygous minor genotype (GG) in the case group was 49.5% (n=100), 40.1% (n=81) and 10.4% (n=21), respectively, and in controls was 49.5% (n=97), 42.3% (n=83) and 8.2% (n=16). Binary logistic regression showed that rs17401966 was not statistically associated with the risk of HCC development in Thai chronic HBV patients (p-value=0.998, OR=1.00 and 95% CI=0.68-1.48). In conclusion, the KIF1B gene SNP (rs174019660) investigated in this study showed no significant association with HBV-related HCC in Thai patients infected with HBV, indicating that there must be other mechanisms or pathways involved in the development of HCC.
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