期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 197, 期 4, 页码 489-501出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20021293
关键词
autoimmunity; immunoregulation; B cells; interleukin 10; CD40
资金
- Arthritis Research UK [17707] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-gamma. Transfer of these B cells into DBA/1-TcR-beta-Tg mice, immunized with bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiation, prevented arthritis development, and was also effective in ameliorating established disease. IL-10 is essential for the regulatory function of this subset of B cells, as the B cells population isolated from IL-10 knockout mice failed to mediate this protective function. Furthermore, B cells isolated from arthritogenic splenocytes treated in vitro with anti-IL-10/anti-IL-10R were unable to protect recipient mice from developing arthritis. Our results suggest a new role of a subset of B cells in controlling T cell differentiation and antoimmune disorders.
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