期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 100, 期 4, 页码 1475-1480出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0437746100
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资金
- NCRR NIH HHS [RR-15044, RR-06591, R01 RR006591, P40 RR015044] Funding Source: Medline
- NICHD NIH HHS [P01 HD037105, HD-37105] Funding Source: Medline
- NIGMS NIH HHS [GM-61005, R01 GM061005] Funding Source: Medline
Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.
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