期刊
CANCER LETTERS
卷 190, 期 2, 页码 165-169出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(02)00593-1
关键词
Chrysobalanaceae; Licania tomentosa; Chrysobalanus icaco; triterpenes; multidrug resistance; leukemia
类别
Plants are known as important source in the search for new anti-cancer agents. Cytotoxicity-guided fractionation of leaves and fruits from Licania tomentosa Bench and leaves from Chrysobalanus icaco L. resulted in the isolation of betulinic, oleanolic and pomolic acids. These triterpenoids inhibited the growth and induced apoptosis of K562, an erythroleukerma cell line. Most importantly, they also inhibited the proliferation of Lucena 1, a vincristine-resistant derivative of K562 that displays several multidrug resistance (MDR) characteristics. Taken together, our findings emphasize the anti-tumor activity of these triterpenes on leukemia cell lines and call attention to their potential as anti MDR agents. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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