期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 4, 页码 633-636出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)01050-8
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Stat3 is a latent transcription factor that exhibits elevated activity in a variety of human cancers. To find a lead peptide for peptidomimetic drug development we synthesized and tested phosphopeptides derived from known receptor docking sites and found Y(p)LPQTV as the optimal sequence, SAR studies showed that each residue from pY to pY + 3 provided binding energy. (C) 2003 Elsevier Science Ltd. All rights reserved.
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