4.7 Article

Nuclear export inhibitor leptomycin B induces the appearance of novel forms of human Mdm2 protein

期刊

BRITISH JOURNAL OF CANCER
卷 88, 期 4, 页码 636-643

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6600752

关键词

leptomycin 3; human Mdm2; p53; proteasome; limited proteolysis

类别

向作者/读者索取更多资源

The nuclear export inhibitor leptomycin B (LIMB) prevents the export of proteins from the nucleus to the cytoplasm, protects p53 from Mdm2-mediated degradation and is a very potent inducer of the p53 transcriptional activity. Here we suggest that LIMB can also interfere with the degradation of human Mdm2. In the presence of this drug, we observed two novel forms of this protein: a slow mobility form and an amino-terminal fragment with an apparent molecular mass of 32 kDa, The presence of this 32 kDa band is abolished with proteasome inhibitors, indicating that its appearance could be because of limited processing by the proteasome. These results may be useful in understanding the mechanism of degradation of Mdm2 by the proteasome. (C) 2003 Cancer Research UK.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据