期刊
FEBS LETTERS
卷 537, 期 1-3, 页码 146-150出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)00113-3
关键词
atherosclerosis; flavanol; flavonol; oxidized LDL; peroxidase; reactive nitrogen species
In the presence of a H2O2-generating system, myeloperoxidase (MPO) caused conjugated diene formation in low-density lipoprotein (LDL), indicating lipid peroxidation which was dependent on nitrite but not on chloride. The oxidation of LDL was inhibited by micromolar concentrations of flavonoids such as (-)-epicatechin, quercetin, rutin, taxifolin and luteolin, presumably via scavenging of the MPO-derived NO2 radical. The flavonoids served as substrates of MPO leading to products with distinct absorbance spectra. The MPO-catalyzed oxidation of flavonoids was accelerated in the presence of nitrite. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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