期刊
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
卷 14, 期 11, 页码 6739-6742出版社
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
DOI: 10.7314/APJCP.2013.14.11.6739
关键词
Apoptotic pathway; Bax gene; breast cancer; Bcl2 gene; oleuropein; p53 gene; semi-quantitative RT-PCR
类别
资金
- National Plan for Science and Technology (NPST)
- King AbdulAziz City for Science and Technology (KACST) [10-ENV993-02]
Background: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis. Materials and Methods: p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells. Results: Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2. Conclusions: Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway.
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