期刊
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
卷 87, 期 2, 页码 1349-1359出版社
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-3765201520140717
关键词
Candida spp.; clinical isolates; epidemiology; fluconazole; resistance
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Coordenacao de Aperfeicoamento Pessoal de Nivel Superior (CAPES)
- Instituto de Microbiologia Paulo de Goes (IMPG)
- Universidade Federal do Rio de Janeiro (UFRJ)
Candidiasis has become an important concern for clinical practice, especially with the increasing incidence of immunocompromised patients. In this scenario, the development resistance to fluconazole presents a challenge for treating these opportunistic infections. The aim of this study was to evaluate some epidemiology features of Candida infections in a Brazilian University Hospital using data, previously unavailable. We observed that 44% of the 93 clinical isolates tested, belonged to Candida albicans species and 56% belonged to non-Candida albicans species (mainly Candida tropicalis and Candida glabrata). Most strains were isolated from urine samples where C. albicans was predominantly detected. 29 strains presented a fluconazole resistance phenotype and of these, 22 were chemosensitised by FK506, a classical inhibitor of ABC transporters related to azoles resistance. These data suggest the probable role of efflux pumps in this resistance phenotype. Our study highlights the need for developing effective control measures for fungal infections, rational use of antifungal drugs and development of new molecules able to abrogate the active transport of antifungals.
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