4.7 Article

Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients

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JOURNAL OF CLINICAL MICROBIOLOGY
卷 41, 期 3, 页码 1277-1279

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AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.41.3.1277-1279.2003

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One hundred forty-six hepatitis B e antigen (HBeAg) -positive chronic hepatitis B patients were followed up for 32 +/- 13 months. All six patients with hepatocellular carcinoma had hepatitis B virus (HBV) genotype C. Disease activity was greater in patients infected by HBV genotype C than in those infected by HBV genotype B in the HBeAg-positive phase but not after HBeAg seroconversion.

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