期刊
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
卷 13, 期 11, 页码 5573-5579出版社
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
DOI: 10.7314/APJCP.2012.13.11.5573
关键词
Fatty acid synthase; onion; MDA-MB-231 cells; 3T3-L1 adipocytes; apoptosis
类别
资金
- Special Science and Technology Projects for Outstanding Young in Life Sciences [KSCX2-EW-Q-19]
- Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences [KSCX2-EW-J-29]
- K.C. Wong Education Foundation, Hong Kong
Onions (Allium cepa L.) are widely used in the food industry for its nutritional and aromatic properties. Our studies showed that ethyl acetate extract of onion (EEO) had potent inhibitory effects on animal fatty acid synthase (FAS), and could induce apoptosis in FAS over-expressing human breast cancer MDA-MB-231 cells. Furthermore, this apoptosis was accompanied by reduction of intracellular FAS activity and could be rescued by 25 mM or 50 mM exogenous palmitic acids, the final product of FAS catalyzed synthesis. These results suggest that the apoptosis induced by EEO occurs via inhibition of FAS. We also found that EEO could suppress lipid accumulation during the differentiation of 3T3-L1 adipocytes, which was also related to its inhibition of intracellular FAS activity. Since obesity is closely related to breast cancer and obese patients are at elevated risk of developing various cancers, these findings suggested that onion might be useful for preventing obesity-related malignancy.
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