期刊
BIOMEDICAL CHROMATOGRAPHY
卷 17, 期 2-3, 页码 113-117出版社
WILEY
DOI: 10.1002/bmc.220
关键词
econazole; etodolac; cromakalim; metoprolol; nebivolol; miconazole; teratolol; tolamolol
The chiral resolution of some clinically used drugs namely metoprolol, teratolol, tolamolol, nebivolol (beta-adrenergic blockers), econazole, miconazole (anti-fungal agents), cromakalim. (anti-hypertensive agent) and etodolac (anti-inflammatory agent) was achieved on cellulose tris (3,5-dichlorophenylcarbamate) chiral stationary phase. The mobile phase used was 2-propanol at 0.5 mL/min with detection at 220 nm. The separation factors (alpha) of these drugs ranged from 1.24 to 3.90 while the resolution factors were from 1.05 to 5.0. The chiral recognition mechanisms between the racemates and the chiral selector are discussed. Copyright (C) 2003 John Wiley Sons, Ltd.
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