期刊
DEVELOPMENTAL NEUROSCIENCE
卷 25, 期 2-4, 页码 116-126出版社
KARGER
DOI: 10.1159/000072261
关键词
glial heterogeneity; neurotrophins; glial development
资金
- NICHD NIH HHS [HD 23315, HD 36647] Funding Source: Medline
To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affecting total cell numbers. In the cortex, however, while NGF and NT-3 influenced MBP expression, BDNF was without effect. To explore this apparent regional difference in BDNF action, we compared expression of the neurotrophin receptors trkA, trkB and trkC. While BF cells expressed all three trks, cortical cells did not express the full-length BDNF receptor, trkB. Interestingly, in no case was any receptor expressed by all oligodendrocytes, indicating that oligodendrocytes may be heterogeneous within a brain region. The data suggest that BF oligodendrocytes are influenced by BDNF to express MBP and are distinct in this ability from cortical cells. Copyright (C) 2003 S. Karger AG, Basel.
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