期刊
JOURNAL OF IMMUNOLOGY
卷 170, 期 5, 页码 2680-2687出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.5.2680
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In prior studies aggregation of the high affinity receptors for IgE, FcepsilonRI, on a rat mast cell line, RBL-2H3, stimulated transcription of the gene for monocyte chemotactic protein-1 (MCP-1) and secretion of the protein. Unexpectedly, those delayed events appeared much less constrained by kinetic proofreading than had been documented for other receptor-initiated responses. The results of the present experiments are consistent with the proposal that the biosynthesis and secretion of MCP-1 result from a soluble messenger formed in the reaction cascades initiated by the receptor, and that Ca2+ could serve as that messenger. Interestingly, whereas receptor-mediated signals were required for transcription of the gene for MCP-1 and secretion of the chemokine, such signals were not required for the intervening step of translation of its mRNA.
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