期刊
EUROPEAN JOURNAL OF BIOCHEMISTRY
卷 270, 期 6, 页码 1240-1248出版社
WILEY
DOI: 10.1046/j.1432-1033.2003.03484.x
关键词
beta-peptide; antimicrobial; peptide-lipid interactions; membrane leakage; membrane intrinsic curvature
资金
- NIGMS NIH HHS [GM56414] Funding Source: Medline
We have studied the interaction of beta-17, a potent synthetic antimicrobial beta-peptide, with phospholipids. We find that unlike other antimicrobial peptides such as magainin II, beta-17 facilitates the formation of nonbilayer phases, indicating that the peptide promotes negative curvature. Studies of liposomal leakage also indicate a different mode of membrane interaction relative to magainin II, but both leakage and membrane binding show that beta-17, like magainin II, has strong affinity for membranes containing anionic lipids. This is likely to be an important factor contributing to the antimicrobial specificity of the beta-peptide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据