期刊
CHEST
卷 123, 期 3, 页码 339S-345S出版社
ELSEVIER SCIENCE BV
DOI: 10.1378/chest.123.3_suppl.339S-a
关键词
adenosine; airway remodeling; interleukin-11; interleukin-13; transforming growth factor-beta(1); vascular endothelial growth factor
Interleukin (IL)-13 is a key cytokine in asthma pathogenesis. We used constitutive and inducible overexpression transgenic mice to characterize the mechanisms by which IL-13 causes phenotypic alterations in the lung. These studies demonstrated that chemokine receptor-2, transforming growth factor-beta(1), and IL-11 play an important role in the regulation,of inflammation and remodeling in the IL-13-treated lung. The study results also demonstrated that IL-13 induces vascular endothelial growth factor, which causes bronchial circulation neovascularization in the murine airway. Last, it was demonstrated that IL-13 induces adenosine accumulation and that adenosine in turn stimulates IL-13 elaboration. These approaches validated in vivo genetic targets against which therapies can be directed to selectively regulate aspects of the IL-13 phenotype.
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