期刊
AMERICAN JOURNAL OF GASTROENTEROLOGY
卷 98, 期 3, 页码 S2-S7出版社
NATURE PUBLISHING GROUP
DOI: 10.1016/S0002-9270(03)00009-1
关键词
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Symptomatic, or nonerosive, gastroesophageal reflux disease (GERD) is the most common presentation of GERD. Patients with symptomatic GERD more frequently are younger, female, weigh less, and are less likely to have a hiatal hernia compared with patients who have erosive GERD. Physiologically, these patients demonstrate minimal esophageal motor abnormalities. However, despite a common clinical presentation and similar endoscopic findings, symptomatic GERD is comprised of a heterogeneous group of patients. There are several identifiable subgroups differentiated by the underlying mechanisms causing their heart-burn symptoms, distinctions that may explain the relatively low symptom response rate to potent antireflux treatment observed among these patients as compared with those with erosive esophagitis.
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