期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 284, 期 3, 页码 E468-E474出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00434.2002
关键词
inflammation; obesity; pigmentation; sexual function; receptor
资金
- NIDDK NIH HHS [1R01 DK-54032-01, P30 DK-34933] Funding Source: Medline
The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and two ancillary proteins. This review provides an abbreviated account of the basic biochemistry, pharmacology, and physiology of the melanocortin system and highlights progress made in four areas. In particular, recent pharmacological and genetic studies have affirmed the role of melanocortins in pigmentation, inflammation, energy homeostasis, and sexual function. Development of selective agonists and antagonists is expected to further facilitate the investigation of these complex physiological functions and provide an experimental basis for new pharmacotherapies.
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