期刊
CLINICS IN LABORATORY MEDICINE
卷 23, 期 1, 页码 65-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/S0272-2712(02)00064-1
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资金
- NIA NIH HHS [P30 AG10133] Funding Source: Medline
Prion protein (PrP) amyloid accumulation is the pathologic hallmark of some inherited prion diseases such as Gerstmann-Straussler-Scheinker disease (GSS) and PrP cerebral amyloid angiopathy (PrP-CAA). In GSS, parenchymal amyloidosis may coexist with spongiform degeneration or neurofibrillary tangles, whereas in PrP-CAA, vascular amyloid coexists with neurofibrillary tangles. In GSS, N-truncated and C-truncated proteinase K-resistant PrP isoforms are present in the brain.
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