期刊
DEVELOPMENT
卷 130, 期 5, 页码 873-887出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.00314
关键词
gradients; morphogenesis; no tail; mediolateral intercalation behavior; notochord; convergence; extension; gastrulation; epiboly; zebrafish
资金
- NICHD NIH HHS [HD22486] Funding Source: Medline
Promptly after the notochord domain is specified in the vertebrate dorsal mesoderm, it undergoes dramatic morphogenesis. Beginning during gastrulation, convergence and extension movements change a squat cellular array into a narrow, elongated one that defines the primary axis of the embryo. Convergence and extension might be coupled by a highly organized cellular intermixing known as mediolateral intercalation behavior (MIB). To learn whether MIB drives early morphogenesis of the zebrafish notochord, we made 4D recordings and quantitatively analyzed both local cellular interactions and global changes in the shape of the dorsal mesodermal field. We show that MIB appears to mediate convergence and can account for extension throughout the dorsal mesoderm.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据