期刊
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
卷 54, 期 3, 页码 550-554出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.TA.0000047049.64695.69
关键词
intracranial pressure; apnea; hypertension; hypoventilation; hyperearbia
Background: Apnea and catecholamine surge have been known sequelae in the first few minutes of postexperimentally induced severe head injury for over a century. However, the intracranial pressure (ICP) response to these two pathophysiologic processes is poorly understood. Methods: We used the rat fluid percussion head injury model to study apnea and catecholamine surge separately and in combination on measured ICP response. Results: The three experimental groups of apnea, hypertensive surge, and both combined revealed significantly different ICP responses with markedly elevated pressures correlating closely with mean arterial blood pressure. Conclusion: ICP and mean arterial blood pressure correlate closely in the first few minutes after head injury in the absence of space-occupying hematomas, and may initiate pathophysiologic sequelae that can only be treated by earlier medical intervention at the scene.
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