期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 17, 期 1, 页码 3-7出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881103017001687
关键词
discounting; gambling; probability; serotonin; tryptophan depletion
Choice behaviour can be viewed as a response to reinforcement determined by an interaction between the quantities, delays and probabilities of two outcomes. The variation in the perceived value of a reinforcer with alteration of these factors (discounting) can be modelled mathematically by hyperbolic discounting functions. Making risky choices is a feature of impulsivity and has been associated with reduced serotonin (5-hydroxytryptamine, 5-HT) function. In this study, we investigated the possible role of 5-HT in modulating probability discounting using the technique of acute tryptophan (TRP) depletion in subjects undertaking an imaginary gambling task. The gambling task consisted of choosing between two `roulette-like' dials: `A' which provided a smaller but nearly certain `win' and `B' which gave a `win' 2.5 times the amount with a probability that was systematically varied. A series of reward sizes on dial `A' was presented ranging from 10 pence to pound10 000. The probability of winning on dial `B' at which the subjects valued the two dials equally (indifference point) was determined as a measure of willingness to take a risk. Subjects were more likely to take a risk for smaller rewards but the indifference points in the 15 subjects who received TRP depletion did not differ from 13 who had the control drink. On a surprise retesting 1 week later there was a trend (p < 0.07) for subjects to be more willing to take risks the second time, particularly in the case of small rewards. This study does not support a role for 5-HT in modulating probabilistic choice in agreement with recent evidence from experiments with animals; however, the imaginal nature of the task and modest numbers may have influenced the result.
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