期刊
EXPERIMENTAL GERONTOLOGY
卷 38, 期 3, 页码 345-346出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0531-5565(02)00208-5
关键词
C. elegans; dauer animals; life-span
The 1 mm long nematode Caenorhabditis elegans is one of the prime animal models to study the genetics of aging. Wild type animals under laboratory conditions live only for an average of 18 days, whereas mutations in about 50 genes have been identified that extend longevity up to sixfold. High-throughput analyses have been devised that allow large-scale analysis to identify additional genes, as well as compounds that affect life-span. (C) 2002 Elsevier Science Inc. All rights reserved.
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