期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 120, 期 6, 页码 1062-1065出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04194.x
关键词
therapy-related acute myeloid leukaemia; myelodysplasia; p15 methylation
类别
Seventeen patients with therapy-related myelodysplastic syndrome/acute myeloid leukaemia (t-MDS/AML) were examined for aberrant p15 gene methylation by methylation-specific polymerase chain reaction. Ten patients (58%) showed p15 methylation, which was significantly related to monosomy/deletion of chromosome 7q, but not to antecedent chemotherapy, blast count, leukaemic evolution or survival. In three of six patients with marrow samples obtained prior to the diagnosis of t-MDS/AML, p15 methylation predated disease development by up to 2 years. Bone marrow transplantation led to the disappearance of p15 methylation in one patient. These results showed that p15 methylation was an early event in the evolution of some t-MDS/AML patients.
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