期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 31, 期 2, 页码 126-132出版社
CAMBRIDGE MED PUBL
DOI: 10.1177/147323000303100209
关键词
galanin; glucose; insulin; pancreatic glucagon; canine
The effect of synthetic galanin on plasma glucose, insulin and pancreatic glucagon levels in dogs was studied. Infusion of galanin caused a rapid, reversible and dose-dependent reduction in basal insulin level. A maximal increase in blood glucose level accompanying the insulin decrease was observed when galanin was administered at a dose of 4 mug/kg per h. Pancreatic glucagon levels showed little change compared with basal secretion. These results indicate that galanin is involved in the regulation of glucose through control of insulin secretion.
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