Correlation analysis between equilibria for addition of semicarbazide and hydroxylamine to several carbonyl compounds and their equilibria for addition of water

Equilibrium constants for semicarbazide and hydroxylamine addition to several carbonyl compounds are reported and compared with those for addition of water. The results are correlated by the linear free relationship log K-add = SW + B, where w is a measure of the reactivity of a given compound to water addition, S is a measure of the sensitivity of the examined reactions compared with the model of hydration equilibrium constants and B is a constant for a given reaction series. Copyright (C) 2003 John Wiley Sons, Ltd.