期刊
SYNAPSE
卷 47, 期 3, 页码 240-242出版社
WILEY-LISS
DOI: 10.1002/syn.10166
关键词
cocaine; conditioned place preference; reward; nicotine; morphine; amphetamine; ethanol; glutamate; mGluR5
We examined the ability of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective antagonist of the type 5 metabotropic glutamate receptor (mGluR5), to reduce the rewarding effect's of various drugs of abuse in the conditioned place preference (CPP) paradigm. Mice were treated with MPEP (1, 5, and 20 mg/kg i.p.) 10 min prior to cocaine (15 mg/kg i.p.), D-amphetamine (2 mg/kg i.p.), nicotine (0.5 mg/kg i.p.), morphine (5 mg/kg i.p.), or ethanol (2 g/kg i.p.) on 3 successive days of CPP conditioning trials. MPEP pretreatment dose-dependently reduced the development of CPP for cocaine only. When tested alone at the doses effective in reducing CPP, MPEP produced neither a place preference nor aversion. These data provide further support for a role of the mGluR5 receptor in the rewarding effects of cocaine. (C) 2002 Wiley-Liss, Inc.
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