期刊
BIOCHEMICAL JOURNAL
卷 370, 期 -, 页码 361-371出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20021626
关键词
phosphoinositide 3-kinase; phosphoinositide-dependent kinase-1 (PDK-1); phosphorylation motif; protein kinase A (PKA); protein kinase B (PKB)/Akt; protein kinase C (PKC)
资金
- NIGMS NIH HHS [GM 43154] Funding Source: Medline
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.
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