期刊
JOURNAL OF VIROLOGY
卷 77, 期 5, 页码 3291-3296出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.5.3291-3296.2003
关键词
-
类别
资金
- NCRR NIH HHS [P41 RR007707, P41 RR002250] Funding Source: Medline
- NIAID NIH HHS [R37 AI036040, P01 AI057788, R01 AI016687, R01 AI036040, AI-36040, AI-16687] Funding Source: Medline
Numerous prior studies have indicated that viable rotavirus reassortants containing structural proteins of heterologous parental origin may express unexpected phenotypes, such as changes in infectivity and immunogenicity. To provide a structural basis for alterations in phenotypic expression, a three-dimensional structural analysis of these reassortants was conducted. The structures of the reassortants show that while VP4 generally maintains the parental structure when moved to a heterologous protein background, in certain reassortants, there are subtle alterations in the conformation of VP4. The alterations in VP4 conformation correlated with expression of unexpected VP4-associated phenotypes. Interactions between heterologous NT4 and VP7 in reassortants expressing unexpected phenotypes appeared to induce the conformational alterations seen in VP4.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据