期刊
DEVELOPMENTAL NEUROSCIENCE
卷 25, 期 2-4, 页码 197-206出版社
KARGER
DOI: 10.1159/000072268
关键词
hepatocyte growth factor; thalamus; cortex; neurite outgrowth; chemoattractant; thalamocortical targeting; ganglionic eminence; axonal guidance; c-met
资金
- NIMH NIH HHS [MH45507, MH12651] Funding Source: Medline
The initial axonal projections between the cerebral cortex and thalamus are established during embryogenesis. Chemoattractants and repellents are thought to provide specific guidance cues for directional growth of these pathways. Hepatocyte growth factor/scatter factor (HGF/SF) serves as an attractant for developing motor neurons, and its distribution in embryonic pallidum, pallium and thalamus suggests a similar role in forebrain development. We examined the effectiveness of HGF/SF in regulating thalamic and cortical neuronal growth using in vitro assays. HGF/SF increased neurite outgrowth of thalamic, but not cortical neurons, grown in dissociated cultures or as explants. HGF/SF also exhibited a chemoattractant property for thalamic axons, promoting the extension of neurites towards an HGF/SF source. These experiments demonstrate HGF/SF has the capacity to selectively direct thalamocortical projections into an intermediate target, the pallidum, and eventually to their final cortical destination. Copyright (C) 2003 S. Karger AG, Basel.
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