期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 136, 期 1-2, 页码 17-24出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00466-6
关键词
immunoglobulin A; saliva; secretion; submandibular gland
Salivary secretion of immunoglobulin A (IgA) by submandibular glands is increased by stimuli from autonomic nerves. Since it is unclear which specific autonomic receptors transduce such stimuli, we have infused autonomimetics intravenously and compared secretion of fluid, IgA and stored proteins (peroxidase and total protein) with secretory responses during electrical stimulation of the parasympathetic nerve supply in anaesthetized rats. The greatest secretion of IgA was evoked by the alpha-adrenoceptor agonist phenylephrine and this was reduced by the beta-adrenoceptor blocking drug propranolol. The secretion of fluid or proteins but not IgA was increased with frequency of nerve stimulation and dose of methacholine (cholinergic), isoprenaline (beta-adrenergic) or phenylephrine (alpha-adrenergic). (C) 2003 Elsevier Science B.V. All rights reserved.
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