期刊
NATURE NEUROSCIENCE
卷 6, 期 3, 页码 243-250出版社
NATURE AMERICA INC
DOI: 10.1038/nn1020
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资金
- NIDCD NIH HHS [DC04213] Funding Source: Medline
- NINDS NIH HHS [NS41963] Funding Source: Medline
The molecular mechanisms underlying polarized sorting of proteins in neurons are poorly understood. Here we report the identification of a 16 amino-acid, dileucine-containing motif that mediates dendritic targeting in a variety of neuronal cell types in slices of rat brain. This motif is present in the carboxy (C) termini of Shal-family K+ channels and is highly conserved from C. elegans to humans. It is necessary for dendritic targeting of potassium channel Kv4.2 and is sufficient to target the axonally localized channels Kv1.3 and Kv1.4 to the dendrites. It can also mediate dendritic targeting of a non-channel protein, CD8.
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