期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 131, 期 3, 页码 490-497出版社
WILEY
DOI: 10.1046/j.1365-2249.2003.02082.x
关键词
human pregnancy; interleukin 12; monocytes; Th1/Th2
类别
This paper considers both monocytes and peripheral blood lymphocytes as potential targets for maternal immunological modulation in pregnancy. Peripheral blood mononuclear cells (PBMCs) from non-pregnant and normal pregnant donors were stimulated in vitro , and cytokine production detected intracellularly by flow cytometry. It was found that monocyte production of TNF-alpha was unaltered in pregnancy, while production of IL-12 was significantly enhanced. In contrast, production of the Th1 type cytokine IFN-gamma was suppressed in the lymphocyte subsets: CD4(+) T helper cells and CD56(+) NK cells. Production of the Th2 type cytokine IL-4 in CD4(+) cells was not significantly altered in pregnancy. These data suggest that the concept that pregnancy is a 'Th2 phenomenon' cannot be generalized to the function of all aspects of maternal cellular immunity as, paradoxically, circulating monocytes are 'primed' to produce the Th1 cytokine IL-12. Furthermore, these data support the hypothesis that components of maternal innate immunity are activated in normal pregnancy.
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