期刊
BIOMARKERS
卷 8, 期 2, 页码 93-109出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1354750021000046570
关键词
naphthol; phenanthrol; pyrenol; naphthalene; pyrene; PAH; urine
资金
- NIEHS NIH HHS [P30ES10126, P42ES05948] Funding Source: Medline
A method was developed for simultaneous quantification of urinary 1- and 2-naphthols, 3- and 9-phenanthrols and 1-pyrenol using gas chromatography with mass spectrometry (GC-MS). This method was applied to urine samples from coke oven workers (n = 28) and controls (n = 22) from Northern China. Geometric mean levels of urinary 1-naphthol (58.8 mug l(-1)), 2-naphthol (34.1 mug l(-1)), 3-phenanthrol (7.35 mug l(-1)), 9-phenanthrol (1.28 mug l(-1)) and 1-pyrenol (25.4 mug l(-1)) were significantly higher among coke oven workers than controls. All the substances tested were highest among top-of-oven workers, who had 15-fold higher 1-naphthol, eight-fold higher 2-naphthol and 20-fold higher I-pyrenol levels compared with controls. Using multiple linear regression models, 72.5% of the variation in 1- and 2-naphthol and 82.8% of the variation in 1-pyrenol were explained by the concentration of naphthalene or pyrene in the urine, the work category and the smoking intensity. Cigarette consumption significantly contributed to levels of urinary 1-pyrenol and naphthols, particularly 2-naphthol. A negative relationship between work category and the ratio of naphthols/1-pyrenol was observed among smokers. Our results suggest that urinary naphthols and phenanthrols reflect polycyclic aromatic hydrocarbon (PAH) exposure as well as the widely used 1-pyrenol, and that interactions between cigarette smoking and PAH exposure result in different patterns of metabolism for individual PAHs.
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