期刊
NATURE REVIEWS CANCER
卷 3, 期 3, 页码 155-168出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1011
关键词
-
类别
Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response - a cornerstone of genome stability - occurs by a swift transduction of the DNA-damage signal to many cellular pathways. A prime example is the cellular response to DNA double-strand breaks, which activate the ATM protein kinase that, in turn, modulates numerous signalling pathways. ATM mutations lead to the cancer-predisposing genetic disorder ataxia-telangiectasia (A-T). Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据