期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 24, 期 3, 页码 107-109出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(03)00027-0
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Salvinorin A, a neoclerodane diterpene, is the most potent naturally occurring hallucinogen known and rivals the synthetic hallucinogen lysergic acid diethylamide in potency. Recently, the molecular target of salvinorin A was identified as the kappa opioid receptor (KOR). Salvinorin A represents the only known non-nitrogenous KOR selective agonist. Based on the selectivity of salvinorin A for the KOR, this receptor represents a potential molecular target for the development of drugs to treat disorders characterized by alterations in perception, including schizophrenia, Alzheimer's disease and bipolar disorder.
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