期刊
NATURE REVIEWS IMMUNOLOGY
卷 3, 期 3, 页码 199-210出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1027
关键词
-
类别
The identification and characterization of regulatory T (T,,g) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4(+) T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4(+)CD25(+) T-Reg cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4(+)CD25(+) T-Reg cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据