期刊
PHARMACOGENOMICS
卷 4, 期 2, 页码 171-178出版社
FUTURE MEDICINE LTD
DOI: 10.1517/phgs.4.2.171.22636
关键词
complex disease; genetic association; haplotype; linkage disequilibrium; population genetics
资金
- NIGMS NIH HHS [GM59507] Funding Source: Medline
Several studies of haplotype structures in the human genome in various populations have been published recently. Such knowledge may provide valuable information on human evolutionary history and lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. in this review, we summarize the current understanding of haplotype structure, diversity, and distribution in the human genome, with a focus on statistical issues in using haplotypes for studies of population genetics and evolutionary history, as well as to identify genetic variants underlying complex human traits.
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