期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 100, 期 5, 页码 2386-2390出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2628030100
关键词
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资金
- NIGMS NIH HHS [P50 GM062412, GM 62412] Funding Source: Medline
One of the principal goals of the structural genomics initiative is to identify the total repertoire of protein folds and obtain a global view of the protein structure universe. Here, we present a 3D map of the protein fold space in which structurally related folds are represented by spatially adjacent points. Such a representation reveals a high-level organization of the fold space that is intuitively interpretable. The shape of the fold space and the overall distribution of the folds are defined by three dominant trends: secondary structure class, chain topology, and protein domain size. Random coil-like structures of small proteins and peptides are mapped to a region where the three trends converge, offering an interesting perspective on both the demography of fold space and the evolution of protein structures.
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