Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR = 1.5, 95% Cl = 1.1-2.2), especially in association with alcohol consumption (P for interaction = 0,04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here. (C) 2003 Cancer Research UK.