期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 51, 期 6, 页码 1671-1675出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf020900u
关键词
angiotensin-converting enzyme inhibitor; oligopeptide; liposome; modification; spontaneously hypertensive rats (SHR)
Synthetic peptides were microencapsulated into liposomes, cycled with a disulfide bond or modified with D-phenylglycine (D-phg) at the N-terminal, and their anti hypertensive effects as orally administered (0.18 mM/kg body weight) to spontaneously hypertensive rats (SHR) were measured. The microencapsulated Leu-Lys-Pro reduced significantly the systolic blood pressures of SHR by 45 mmHg and showed a prolonged duration, revealing the significant protective effect of encapsulation. D-phg-Leu-Arg-Pro showed a duration about 2 h shorter than that of the peptide without modification. In addition, cyclic Leu-Arg-Pro peptide with a disulfide bond between the N- and C-terminal amino acids reduced the systolic blood pressure of SHR by 35 mmHg and displayed a lengthy duration.
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