期刊
MOLECULAR BRAIN RESEARCH
卷 111, 期 1-2, 页码 182-188出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(03)00029-9
关键词
hallucinogen; 5-HT2A; gene expression; prefrontal cortex; serotonin
资金
- NIDA NIH HHS [F32 DA005993, DA05993, DA05181] Funding Source: Medline
Lysergic acid diethylamide (LSD) is a psychoactive drug that transiently alters human perception, behavior, and mood at extremely low doses. Certain aspects of the behavior elicited by acute doses of LSD closely resemble symptoms of mental disorders such as schizophrenia. Characterizing gene expression profiles after LSD will be important for understanding how it alters behavior, and will lead to novel insights into disorders, such as schizophrenia, whose behavioral symptoms resemble the temporary effects of hallucinogenic drugs. We previously identified a small collection of genes within the rat prefrontal cortex that respond to LSD. Many of the products of these genes are involved in the process of synaptic plasticity. In the current report, we present a detailed analysis of the expression of these genes within the brain using RNase protection analysis. We find that the gene response to LSD is quite dynamic. The expression of some genes increases rapidly and decreases rapidly, while other genes change more gradually. Dose-response studies show two classes of expression; gene expression maximally stimulated at lower doses, versus gene expression that continues to rise at the higher doses. The role of the 5-HT1A and 5-HT2A receptor in mediating the increases in gene expression was examined in a series of experiments using receptor specific antagonists. Most expression increases were due to activation of the 5-HT1A receptor, however expression of two genes had neither a 5-HT A nor a 5-HT2A receptor component. (C) 2003 Elsevier Science B.V. All rights reserved.
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