期刊
NEUROSCIENCE LETTERS
卷 339, 期 2, 页码 99-102出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(02)01483-0
关键词
Alzheimer's disease; beta-amyloid; biochemical markers; cerebrospinal fluid; tau; phospho-tau; magnetic resonance imaging
Biomarkers to monitor the degenerative process in Alzheimer's disease would be of great value. We examined the relation between cerebrospinal fluid (CSF) total tau (T-tau), phospho-tau (P-tau) and Abeta42 and magnetic resonance imaging (MRI) measures of brain atrophy. CSF was taken at baseline and MRI at baseline and at 16 months follow-up. At baseline, statistically significantly lower Abeta42 were found with lower brain volume (r = 0.55; P < 0.0001) and larger ventricular volume (r = -0.53; P < 0.001). In contrast, statistically significantly higher T-tau (r = 0.47; P < 0.001) and P-tau (r = 0.41; P = 0.005) were found with more marked ventricular widening during the follow-up period. These results suggest that Abeta42 in CSF reflects the stage of the disease, with lower CSF levels as the disease progresses, while T-tau and P-tau reflect the intensity of the disease process, with higher CSF-levels with a more rapid progression. (C) 2003 Published by Elsevier Science Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据