期刊
INTERNATIONAL JOURNAL OF CANCER
卷 104, 期 2, 页码 161-166出版社
WILEY
DOI: 10.1002/ijc.10929
关键词
TGF-beta receptor (types I, II); TGF-beta 1; esophageal squamous cell carcinoma; imnumohistochemistry
类别
Transforming growth factor-beta (TGF-beta) inhibits epithelial cell proliferation. Inactivation of the TGF-beta signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF-beta receptors or TGF-betaI expression and the clinicopathologic characteristics of patients with esophageal squamous cell carcinoma (SCC). Immunohistochemical staining for TGF-beta type I receptor (TGF-betaR-I), TGF-betaR-II and TGF-betaI was performed on surgical specimens obtained from 80 patients with esophageal SCC. Preoperative plasma TGF-betaI levels were measured and correlated with pathologic features and clinical outcomes. Expression of TGF-betaR-I and TGF-betaR-II was reduced in 43 (53.8%) and 23 (28.8%) specimens, respectively. TGF-betaI was overexpressed in 29 (36.3%). Reduced expression of TGF-betaR-I and TGF-betaR-II showed a significant association with depth of invasion (p = 0.0015 and p = 0.0012), lymph node metastasis (p = 0.0309 and p = 0.009) and pathologic stage (p = 0.0103 and p = 0.0401). Overexpression of TGF-betaI had a significant association with depth of invasion only (p = 0.0335). Reduced expression of TGF-betaR-I and TGF-betaR-II was correlated with cancer-specific survival (p = 0.0324 and p = 0.0243). The mean preoperative plasma TGF-betaI level was 10.5 +/- 0.8 ng/ml in patients with esophageal carcinoma and was significantly higher compared to healthy controls (p < 0.01). We demonstrate that reduced expression of TGF-beta receptors in esophageal SCC appears to be correlated with depth of invasion, lymph node metastasis, pathologic stage and poor prognosis. TGF-beta receptor expression may play a key role in the progression of this cancer. (C) 2003 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据