4.8 Article

Percolation, morphogenesis, and Burgers dynamics in blood vessels formation

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PHYSICAL REVIEW LETTERS
卷 90, 期 11, 页码 -

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AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.90.118101

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Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.

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