期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 68, 期 6, 页码 2143-2150出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo026847q
关键词
-
资金
- NIGMS NIH HHS [GM-57212] Funding Source: Medline
Multiple-component condensations (MCC) where three or more reactants combine to afford a new core structure possessing the molecular features of its composite building blocks is a powerful method for the preparation of molecular diversity. We have developed an efficient, nickel-catalyzed, Reformatsky-type three-component condensation (3CC) reaction that affords beta-amino carbonyl compounds. The scope of the reaction is demonstrated both in the gram and microscale settings; 15 beta-amino esters, amides, and a ketone were prepared efficiently at the mmol scale, and a library of 64 beta-amino carbonyl compounds was generated at the mumol scale.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据